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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Nucl Med Biol. 2014 Aug 13;42(1):19–27. doi: 10.1016/j.nucmedbio.2014.08.007

Table 1.

Paired-label biodistribution of trastuzumab labeled with NHS-[131I]IB-d-EEEG and Mal-d-GEEEK-[125I]IB in athymic mice bearing subcutaneous BT474M1 human breast carcinoma xenografts.

Organ/Tissue %ID/g a
4h 12h 24h 48h 96h 144h
Iodine-131
Liver 12.87 ± 1.53 5.40 ± 0.72 4.68 ± 0.61 3.53 ± 0.24 2.44 ± 0.65 1.28 ± 0.26
Spleen 21.94 ± 5.32 11.92 ± 3.31 11.37 ± 2.63 7.89 ± 0.58 5.54 ± 2.51 2.54 ± 1.01
Lungs 10.45 ± 1.95 5.53 ± 0.42 5.08 ± 0.41 4.03 ± 0.40 3.28 ± 1.18 1.70 ± 0.51b
Heart 6.69 ± 1.08 3.60 ± 1.11 3.01 ± 0.52 2.38 ± 0.49 1.73 ± 0.63 0.93 ± 0.33b
Stomach 1.55 ± 0.74 1.23 ± 0.13 1.43 ± 0.38 1.11 ± 0.33 0.55 ± 0.17 0.31 ± 0.09
Small intestine 2.77 ± 0.49 1.71 ± 0.19 1.70 ± 0.36 1.28 ± 0.06 0.87 ± 0.26 0.43 ± 0.10
Large intestine 2.65 ± 0.21b 1.92 ± 0.42b 1.83 ± 0.43 1.60 ± 0.45 0.81 ± 0.33 0.53 ± 0.26
Thyroid 0.60 ± 0.19b 0.32 ± 0.12 0.41 ± 0.15 0.29 ± 0.07 0.19 ± 0.12 0.12 ± 0.03b
Muscle 1.30 ± 0.26 1.25 ± 0.19 1.21 ± 0.14 0.96 ± 0.15 0.67 ± 0.16 0.33 ± 0.11b
Blood 21.92 ± 6.42 10.92 ± 1.45 10.04 ± 0.59 7.55 ± 0.96 5.68 ± 2.07 2.72 ± 0.75b
Bone 2.41 ± 0.38 1.49 ± 0.16 1.47 ± 0.20 1.17 ± 0.19 0.79 ± 0.22 0.42 ± 0.14
Brain 0.74 ± 0.11 0.35 ± 0.06 0.34 ± 0.03 0.27 ± 0.03 0.21 ± 0.08 0.10 ± 0.02b
Iodine-125
Liver 13.25 ± 1.60 6.45 ± 0.91 5.72 ± 0.67 4.53 ± 0.49 3.15 ± 0.59 1.76 ± 0.39
Spleen 25.83 ± 6.27 14.00 ± 3.78 13.47 ± 3.21 10.03 ± 0.61 7.21 ± 2.88 3.54 ± 1.09
Lungs 12.00 ± 2.29 6.49 ± 0.55 6.32 ± 0.59 4.88 ± 0.50 3.62 ± 1.33 1.67 ± 0.58
Heart 7.63 ± 1.25 4.18 ± 1.22 3.57 ± 0.64 2.81 ± 0.52 1.91 ± 0.73 0.92 ± 0.34
Stomach 1.68 ± 0.81 1.60 ± 0.13 1.92 ± 0.57 1.53 ± 0.37 0.76 ± 0.21 0.39 ± 0.12
Small intestine 3.04 ± 0.56 1.97 ± 0.18 2.00 ± 0.44 1.55 ± 0.09 1.02 ± 0.30 0.48 ± 0.11
Large intestine 2.51 ± 0.43 2.23 ± 0.48 1.89 ± 0.41 1.96 ± 0.58 1.04 ± 0.47 0.64 ± 0.30
Thyroid 0.64 ± 0.22 0.37 ± 0.12 0.50 ± 0.18 0.44 ± 0.09 0.51 ± 0.25 0.49 ± 0.19
Muscle 1.54 ± 0.34 1.43 ± 0.23 1.45 ± 0.17 1.15 ± 0.17 0.74 ± 0.17 0.33 ± 0.11
Blood 24.88 ± 7.22 12.41 ± 1.54 11.84 ± 0.77 8.89 ± 1.18 6.42 ± 2.53 2.76 ± 0.90
Bone 2.79 ± 0.51 1.72 ± 0.14 1.83 ± 0.22 1.48 ± 0.19 0.97 ± 0.28 0.58 ± 0.19
Brain 0.85 ± 0.13 0.40 ± 0.07 0.41 ± 0.03 0.32 ± 0.03 0.24 ± 0.10 0.10 ± 0.02
a

Values are mean %ID/g ± SD (n = 5) except for thyroid which %ID/organ is used;

b

No significant difference between the two tracers (P > 0.05)