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. Author manuscript; available in PMC: 2016 Jan 22.
Published in final edited form as: Neuroscience. 2014 Oct 18;0:483–499. doi: 10.1016/j.neuroscience.2014.10.018

Figure 5. The TRPA1 antagonist HC-0300310031 blocks nicotine-evoked fast current.

Figure 5

(A) HC-030031 (10 μM) completely blocked current evoked with the TRPA1 selective agonist AITC (100 μM). (B) HC-030031 had no detectable influence on the slow current evoked by nicotine (300 μM) in cutaneous DRG neurons. (C) However, the fast current was completely blocked by HC-030031. (D) Application of MLA (20 nM), which blocks the fast current, did not influence the AITC-evoked current. (E-H) Neurons were first challenged with nicotine (300 μM) and then AITC (100 μM) 4 min later. (E) A neuron with fast current but no AITC-evoked current; (F) A neuron with AITC-evoked current but no fast current; (G) A neuron with both currents. (H) Pooled data from 20 neurons show the proportions of these 3 populations of neurons are similar.