Table 3.
Summary of the studies discussed regarding the role of baroreflex sensitivity in the pathophysiology of essential hypertension.
| Author | GRADE | Year published | Sample size (n=) | BP (Mean ± SD; mmHg) | BRS analysis method | Findings |
|---|---|---|---|---|---|---|
| Okada et al. [16] | Low | 2012 | 61 | SBP/DBP: 124 ± 3/73 ± 2 | Calculated using DBP and MSNA | Lower BRS may predispose to hypertension |
| Hesse et al. [17] | Low | 2007 | 50 | SBP/DBP: 117 ± 7/70 ± 6 | Calculating using BP and HRV. | BRS was inversely correlated with MAP (p < 0.001; R = 0.49) |
| Mattace-Raso et al. [18] | Moderate | 2007 | 4573 | MAP available only: 106.7 ± 12.6 | Calculating using BP and HRV. | Arterial stiffness was an independent determinant of impaired BRS |
BP = blood pressure; SBP = systolic blood pressure; DBP = diastolic blood pressure; MAP = mean arterial blood pressure; BRS = baroreflex sensitivity; HRV = heart rate variability; MSNA = muscle sympathetic nerve activity. GRADE: The Grades of Recommendation, Assessment, Development and Evaluation.