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. Author manuscript; available in PMC: 2014 Dec 17.
Published in final edited form as: Exp Cell Res. 2010 May 7;316(18):3028–3033. doi: 10.1016/j.yexcr.2010.05.002

Fig. 1.

Fig. 1

Schematic representation of Notch signaling in myoblasts and its interactions with other pathways. CSL interacts with transcriptional corepressors (CoR) in the absence of signaling and with coactivators, including Mastermind (MAML), when bound by NICD. This process is enhanced by the binding of Smad proteins (activated by TGFß), Hif1α (stabilized by hypoxia) and Foxo1 (inactivated by Insulin). Relevant gene targets include those encoding Hey1, MyoR and possibly many others. Protein products of the Notch target genes repress transcription of pro-myogenic genes, shown here to be activated by MyoD and Mef2C, through multiple mechanisms, including targeted repression by Hey1.