Table 3.

Secondary Efficacy End-Point Analysis (Evaluable Population, n=20)

	LS mean*		p value*
	Placebo	MPH-MLR	Treatment	Covariate	Sequence	Period
Average SKAMP scores over all postdose time points
Attention	1.81	1.05	0.0001	0.0002	0.4780	0.0770
Deportment	1.64	0.78	0.0008	0.0108	0.7346	0.1076
Average PERMP math test scores over all postdose time points
PERMP-A	83.15	113.75	0.0054	<0.0001	0.7241	0.1270
PERMP-C	73.19	109.13	0.0006	<0.0001	0.3286	0.0317

^*Mixed-effects analysis of covariance with fixed terms for treatment, sequence, period, random term for participant within sequence, and covariate term for the predose value.

LS, least-squares; MPH-MLR, extended-release multilayer bead methylphenidate; PERMP, Permanent Product Measure of Performance; PERMP-A, Permanent Product Measure of Performance, number of math problems attempted; PERMP-C Permanent Product Measure of Performance, number of math problems answered correctly; SKAMP, Swanson, Kotkin, Agler, M-Flynn, and Pelham.