Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2014 Dec 17;4:7461. doi: 10.1038/srep07461

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2014, Macmillan Publishers Limited. All rights reserved

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder in order to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

PMC Copyright notice

ISH was used to determine the expression of miR-21 in treated OSCC cells; and Western blot was used to detect the expression of its target genes. (a) In Tca8113 and Tca8113/DDP cells, WP1066 combined with DDP treatment could inhibit MMP2/9, Bcl-2, mTOR, Ki67 expression, while in DDP + WP1066 treated group, Caspase-3 expression was upregulated. (b) In Tca8113 and Tca8113/DDP cells, WP1066 combined with DDP treatment could induce the expression of miR-21 (Red signal labeled by Cy3, cell nuclei was labeled by DAPI). IL-6 treatment could inhibit the expression of miR-21. (Bar = 20 μm) (c) In Tca8113 and Tca8113/DDP cells, DDP + WP1066 treatment could induce the expression of PTEN, TIMP3 and PDCD4. While IL-6 treatment could inhibit their expression in both cell lines. The gels were cropped, but those gels were run under the same experimental condition.