Table 2. Univariate and multivariate statistics of the prognostic value of gender, age, size, lymph node metastasis, stage, and SPARC methylation for survival (5 years) in intestinal gastric cancer patients.
| No. (%) | Methylation (%) | Unmethylation (%) | Univariate | Multivariate | ||||
|---|---|---|---|---|---|---|---|---|
| Parameters | N = 185 | N = 136 | N = 49 | P-Value | P-Value | Risk ratio | 95% CI | P-value |
| Gender | bP = 0.613 | P = 0.942 | 1.268 | 0.892–1.803 | P = 0.185 | |||
| Male | 100 (54.1) | 72(72.0) | 28(28.0) | |||||
| Female | 85 (45.9) | 64(75.3) | 21(24.7) | |||||
| Age (years) | bP = 0.271 | P = 0.154 | 1.045 | 0.731–1.494 | P = 0.810 | |||
| ≥63a | 103 (55.7) | 79(76.7) | 24(23.3) | |||||
| <63 | 82 (44.3) | 57(69.5) | 25(30.5) | |||||
| Size (cm) | bP < 0.001 | P = 0.002 | 3.784 | 1.332–10.747 | P = 0.012 | |||
| <2.5 | 19 (10.3) | 5(26.3) | 14(73.7) | |||||
| ≥2.5 | 166 (89.7) | 131(78.9) | 35(21.1) | |||||
| TNM stage | bP < 0.001 | P = 0.007 | 2.334 | 1.351–4.034 | P = 0.002 | |||
| I, II | 37 (20.0) | 14(37.8) | 23(62.2) | |||||
| III, IV | 148 (80.0) | 122(82.4) | 26(17.6) | |||||
| Lymph node metastasis | bP = 0.010 | P = 0.001 | 1.824 | 1.100–3.024 | P = 0.020 | |||
| Negative | 37(20.0) | 21(56.8) | 16(43.2) | |||||
| Positive | 148 (80.0) | 115(77.7) | 33(22.3) | |||||
| SPARC methylation | P < 0.001 | 2.754 | 1.780–4.261 | P < 0.001 | ||||
| - | 49 (26.5) | |||||||
| + | 136 (73.5) | |||||||
Prognostic factors for overall survival was conducted by univariate analyses using the log-rank test and multivariate analyses using the Cox proportional hazards model. CI, confidence interval.
aDivided by median age of adenocarcinoma cases.
bPearson's χ2 test