Table 2. Univariate and multivariate statistics of the prognostic value of gender, age, size, lymph node metastasis, stage, and SPARC methylation for survival (5 years) in intestinal gastric cancer patients.
No. (%) | Methylation (%) | Unmethylation (%) | Univariate | Multivariate | ||||
---|---|---|---|---|---|---|---|---|
Parameters | N = 185 | N = 136 | N = 49 | P-Value | P-Value | Risk ratio | 95% CI | P-value |
Gender | bP = 0.613 | P = 0.942 | 1.268 | 0.892–1.803 | P = 0.185 | |||
Male | 100 (54.1) | 72(72.0) | 28(28.0) | |||||
Female | 85 (45.9) | 64(75.3) | 21(24.7) | |||||
Age (years) | bP = 0.271 | P = 0.154 | 1.045 | 0.731–1.494 | P = 0.810 | |||
≥63a | 103 (55.7) | 79(76.7) | 24(23.3) | |||||
<63 | 82 (44.3) | 57(69.5) | 25(30.5) | |||||
Size (cm) | bP < 0.001 | P = 0.002 | 3.784 | 1.332–10.747 | P = 0.012 | |||
<2.5 | 19 (10.3) | 5(26.3) | 14(73.7) | |||||
≥2.5 | 166 (89.7) | 131(78.9) | 35(21.1) | |||||
TNM stage | bP < 0.001 | P = 0.007 | 2.334 | 1.351–4.034 | P = 0.002 | |||
I, II | 37 (20.0) | 14(37.8) | 23(62.2) | |||||
III, IV | 148 (80.0) | 122(82.4) | 26(17.6) | |||||
Lymph node metastasis | bP = 0.010 | P = 0.001 | 1.824 | 1.100–3.024 | P = 0.020 | |||
Negative | 37(20.0) | 21(56.8) | 16(43.2) | |||||
Positive | 148 (80.0) | 115(77.7) | 33(22.3) | |||||
SPARC methylation | P < 0.001 | 2.754 | 1.780–4.261 | P < 0.001 | ||||
- | 49 (26.5) | |||||||
+ | 136 (73.5) |
Prognostic factors for overall survival was conducted by univariate analyses using the log-rank test and multivariate analyses using the Cox proportional hazards model. CI, confidence interval.
aDivided by median age of adenocarcinoma cases.
bPearson's χ2 test