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. 2014 Dec 5;5:5648. doi: 10.1038/ncomms6648

Figure 1. Validation of intestinal specific deletion of MyD88.

Figure 1

(a) The tamoxifen induction of the intestinal epithelial MyD88 deletion in adult mice (8-week-old mice) is associated with a drastic decrease in MyD88 mRNA expression, specifically in the intestine. mRNA expression of MyD88 in the liver, jejunum, ileum, colon and kidney (n=7). (b) The residual expression of MyD88 corresponds to the other cell types than intestinal epithelial cells since the expression of MyD88 was reduced to almost undetectable values in isolated epithelial cells from IEC MyD88 KO mice (n=4). These data correspond to the results of one experiment. All the replicates represent biological replicates. Data are shown as the means±s.e.m. Data with * are significantly different (P<0.05) according to the unpaired two-tailed Student’s t-test. Data with different superscript letters are significantly different (P<0.05) according to the one-way analysis of variance statistical analysis followed by Newman–Keuls post hoc tests after normalization by log transformation.