Figure 9. Therapeutic effect of IECMyD88 deletion observed in obese and type 2 diabetic mice.
(a) Fat mass weight evolution (g) after 6 weeks of dietary treatment and following 7 weeks after intestinal MyD88 deletion (n=10). Arrow with the word ‘induction’ indicates tamoxifen injection and thereby intestinal MyD88 deletion. (b) Fasted plasma glucose at the end of the experiment (n=10). (c,d) CD11c mRNA and MCP1 mRNA, respectively (n=10 per group). These data correspond to the results of one experiment. All the replicates represent biological replicates. Data are shown as the means±s.e.m. Data with different superscript letters are significantly different (P<0.05) according to the one-way analysis of variance statistical analysis followed by Newman–Keuls post hoc tests after normalization by log transformation (b–d) or two-way statistical analysis followed by Bonferroni post hoc tests (a).