Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2012 Oct 25;7(30):2333–2339. doi: 10.3969/j.issn.1673-5374.2012.30.002

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright: © Neural Regeneration Research

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Effect of different doses of oxymatrine on lipopolysaccharide (LPS)-induced production of toll-like receptor 4 (TLR4) mRNA and protein.

(A) The mRNA expression of TLR4 in the hippocampus was tested by real-time quantitative PCR. Data were plotted as relative quantity (RQ, RQ=2^-ΔΔCT). The expression of the target gene in the sham-operated group was standardized to one, and the RQ values of the other groups represent the fold changes compared with the sham-operated group.

(B) Representative western blot analysis of TLR4 protein (89-kDa) in the cerebral cortex of the different groups. β-actin (43-kDa) was used as a control. I–V: Sham, LPS, high, medium, low dose oxymatrine groups, respectively.

(C) Graph showing changes in the levels of TLR 4 in the different groups.

Data are expressed as mean ± SD (A, RQ; B, ratio of the absorbance value of TLR 4 to that of β-actin), there are three rats in each group. ^aP < 0.05, ^bP < 0.01, vs. sham-operated (Sham) group; ^cP < 0.05, ^dP < 0.01, vs. LPS group, by one-way analysis of variance followed by a Scheffé test.