Table 8.
Risk of nonocular adverse effects
| Study ID | Comparison | Type of complication | Results |
|---|---|---|---|
| Aminocaproic acid | |||
| Kraft 1987 | Oral aminocaproic acid vs. placebo | Nausea | Drug group: 8 of 24; placebo group 1 of 25 |
| Kutner 1987 | Oral aminocaproic acid vs. placebo | Nausea or vomiting | Drug group: 6 of 21; placebo group: 0 of 13 |
| Light headedness | Drug group: 7 of 21; placebo group: 1 of 13 | ||
| Systemic hypotension | Drug group: 4 of 21; placebo group: 1 of 13 | ||
| Total complications | Drug group: 10 of 21; placebo group: 1 of 13 | ||
| McGetrick 1983 | Oral aminocaproic acid vs. placebo | Nausea or vomiting | Drug group: 6 of 28; placebo group: 0 of 20 |
| Diarrhea | Drug group: 2 of 28; placebo group: 0 of 20 | ||
| Muscle cramps | Drug group: 1 of 28; placebo group: 0 of 20 | ||
| Pieramici 2003 | Topical aminocaproic acid vs. placebo | Systemic hypotension | Drug group: 3 of 24; placebo group: 3 of 27 |
| Crouch 1997 | Oral vs. topical aminocaproic acid | Dizziness, nausea, vomiting | Oral group: 5 of 29; topical group: 1 of 35 |
| Palmer 1986 | Low-dose vs. standard-dose oral aminocaproic acid | Nausea or vomiting | Low-dose group: 5 of 25; standard-dose group: 9 of 33 |
| Dizziness and hypotension | Low-dose group: 0 of 25; standard-dose group: 5 of 33 | ||
| Syncope | Low-dose group: 0 of 25; standard-dose group: 2 of 33 | ||
| Diarrhea | Low-dose group: 1 of 25; standard-dose group: 0 of 33 | ||
| Rash or pruritis | Low-dose group: 1 of 25; standard-dose group: 2 of 33 | ||
| Hot flashes | Low-dose group: 1 of 25; standard-dose group: 0 of 33 | ||
| Dry mouth or nose | Low-dose group: 1 of 25; standard-dose group: 0 of 33 | ||
| Farber 1991 | Oral aminocaproic acid vs. oral prednisone | Any adverse event | Aminocaproic acid group: 0 of 56; prednisone group; 0 of 56 |
| Tranexamic acid | |||
| Welsh 1983 | Tranexamic acid vs. placebo | Nausea | Drug group: 1 of 19; placebo group: 0 of 20 |
| Rahmani 1999 | Tranexamic acid vs. placebo | Nausea | Drug group: 0 of 80; placebo group: 0 of 80 |
| Aminomethylbenzoic acid | |||
| Liu 2002 | Oral aminomethylbenzoic acid vs. placebo | Nausea and vomiting | Drug group: 7 of 60; placebo group: NR |
NR: not reported.