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. 2014 Dec 3;12:224. doi: 10.1186/s12916-014-0224-0

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© Keller et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Up- versus downregulations. The balloon plot shows, for the different miRNAs, how many diseases the miRNAs are up- and respectively downregulated in. The bubble size represents the number of miRNAs showing this distribution in up- and downregulation. Orange bubbles belong to predominantly downregulated while blue bubbles belong to predominantly upregulated miRNAs. The two green bubbles represent 9 miRNAs that were equally up- and downregulated in disease.