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. 2014 Dec 5;15(12):551. doi: 10.1186/s13059-014-0551-7

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© Wang et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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EJC-dependent splicing changes are specific to EJC core protein. (A) Western blot (left) and qPCR (right) showing the KD efficiency of EJC core proteins as well as EJC associated protein Acinus, and SR proteins SRSF1 and SRSF2. GAPDH is used as a control. (B,C) RT-PCR of splicing patterns of representative constitutive exons (B) and alternative exons (C) in different KD conditions. The quantification of triplicate experiments are shown below as mean ± SD. *P < 0.05; **P < 0.01; ***P < 0.001, one-way ANOVA.