Table 4.
Multivariate analysis of volumetric parameter cut-off values compared to survival outcomes
| LRPFS | PFS | OS | ||||
|---|---|---|---|---|---|---|
| HR (95% CI) | p | HR (95% CI) | p | HR (95% CI) | p | |
| Sex (Male vs. Female) | NS | NS | NS | |||
| Histology (SqCC vs. Others) | NS | 1.455 (0.983–2.155) | 0.061 | NS | ||
| T stage (T1-T2 vs. T3-T4) | NS | NS | NS | |||
| N stage (N0-N2 vs. N3) | NS | NS | NS | |||
| Stage (IIIA vs. IIIB) | NS | NS | NS | |||
| GTVpre (≤ 50 cm3 vs. > 50 cm3) | 2.926 (1.495–5.726) | 0.002 | 2.001 (1.159–3.454) | 0.013 | 2.763 (1.552–4.919) | 0.001 |
| GTVpost (≤ 20 cm3 vs. > 20 cm3) | NS | 1.467 (0.947–2.273) | 0.086 | NS | ||
| VRR (≤ 50% vs. > 50%) | NS | NS | 1.895 (0.937–3.832) | 0.075 | ||
Abbreviations: CI Confidence interval, GTV pre Initial gross tumor volume CT, GTV post follow-up gross tumor volume, HR Hazard ratio, LRPFS Locoregional progression-free survival rate, NS No significance, OS Overall survival rate, PFS Progression-free survival rate, SqCC Squamous cell carcinoma, VRR Reduction ratio of gross tumor volume.