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. Author manuscript; available in PMC: 2015 Jun 12.
Published in final edited form as: Nat Commun. 2014 Dec 12;5:5797. doi: 10.1038/ncomms6797

Figure 4. Simultaneous downregulation of KLF5 and Fli1 is a molecular hallmark of SSc dermal fibroblasts.

Figure 4

(a,b) Dermal fibroblasts have distinct expression patterns with KLF5 and Fli1 staining in a variety of fibrotic diseases. Representative pictures from n = 5 individuals per group are shown. (a) KLF5 staining. (b) Fli1 staining. Scale bar, 50 μm. (c) Correlation between KLF5 and Fli1 mRNA expression levels in cultured fibroblasts from systemic sclerosis (SSc) patients. KLF5 and Fli1 expressions were quantified by qRT-PCR. Samples from 6 diffuse cutaneous SSc patients were used. Five were positive for anti-topoisomerase I antibody and one was negative for anti-nuclear antibody. Ab, antibody. SSc, systemic sclerosis.