Table 2.
Pharmacokinetic parameters of Taxotere and DCT-loaded LHSA5 nanoparticles after a single intravenous injection (8 mg/kg) in rats (n=4)
| Parameter | Taxotere | LHSA5/DCT |
|---|---|---|
| AUC (μg min/mL) | 75.075±10.191 | 186.767±24.621* |
| Terminal t1/2 (min) | 38.024±6.265 | 121.789±11.805* |
| CL (mL/min/kg) | 100.374±15.558 | 39.441±4.999* |
| Vss (mL/kg) | 5,401.316±131.480 | 6,910.463±979.348 |
| MRT (min) | 23.466±2.227 | 85.432±4.043* |
Notes: Data presented as mean ± SD (n=4).
*
P<0.05 compared with Taxotere group.
Abbreviations: DCT, docetaxel; LHSA, LMWH-SA; LMWH, low-molecular-weight heparin; SA, stearylamine; AUC, total area under the plasma concentration–time curve from time zero to the end time point; CL, time-averaged total body clearance; Vss, the apparent volume of the distribution under steady-state conditions; MRT, the mean residence time; SD, standard deviation.