Table 5.

Key gene list of signaling pathways related to AS.

Signaling pathway	NCBI gene ID	Gene name	Fold change absolute	P value	Regulation	Description
MAPK	1843	DUSP1	3.89	0.02027	Up	Dual specificity phosphatase 1
MAPK	2768	GNA12	3.70	0.02885	Up	Guanine nucleotide binding protein (G protein) alpha 12
MAPK	5879	RAC1	3.15	0.00019	Up	RAS-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
MAPK	22808	MRAS	3.14	0.00491	Up	Muscle RAS oncogene homolog
MAPK	2002	ELK1	2.80	0.01115	Up	ELK1, member of ETS oncogene family
MAPK	5595	MAPK3	2.73	0.01417	Up	Mitogen-activated protein kinase 3
MAPK	994	CDC25B	2.66	0.03507	Up	Cell division cycle 25B
MAPK	468	ATF4	2.50	0.04995	Up	Activating transcription factor 4 (tax-responsive enhancer element B67)
MAPK	3925	STMN1	2.47	0.01463	Up	Stathmin 1/oncoprotein 18
MAPK	4149	MAX	2.31	0.00410	Up	MYC associated factor X
MAPK	7048	TGFBR2	2.18	0.03642	Up	Transforming growth factor, beta receptor II (70/80 kDa)
MAPK	5600	MAPK11	2.12	0.04901	Up	Mitogen-activated protein kinase 11
MAPK	784	CACNB3	2.04	0.03028	Up	Calcium channel, voltage-dependent, beta 3 subunit
MAPK	2253	FGF8	3.49	0.03611	Down	Fibroblast growth factor 8 (androgen-induced)
MAPK	5922	RASA2	2.83	0.01406	Down	RAS p21 protein activator 2
TLR	7187	TRAF3	2.86	0.03732	Up	TNF receptor-associated factor 3
TLR	3454	IFNAR1	2.37	0.01055	Up	Interferon (alpha, beta, and omega) receptor 1
TLR	148022	TICAM1	2.23	0.02105	Up	Toll-like receptor adaptor molecule 1
TLR	3569	IL6	2.18	0.01526	Up	Interleukin 6 (interferon, beta 2)
TLR	5879	RAC1	3.15	0.00019	Up	RAS-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
TLR	5595	MAPK3	2.73	0.01417	Up	Mitogen-activated protein kinase 3
TLR	5600	MAPK11	2.12	0.04901	Up	Mitogen-activated protein kinase 11
TLR	3439	IFNA1	2.62	0.03022	Down	Interferon, alpha 1