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. 2014 Dec 17;8:425. doi: 10.3389/fncel.2014.00425

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Copyright © 2014 Campbell, Hablitz and Olsen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Astrocytes in the hyperexcitable zone display altered electrophysiological properties. (A) Representative whole-cell current responses to a voltage step protocol in an astrocyte in a slice from a sham-operated control and (B) a recording obtained from an astrocyte in slice from a lesioned animal. Inset shows current displayed at higher resolution. (C) Representative whole-cell currents from sham-operated (black) and lesioned (blue) astrocytes in response to a linear voltage ramp (−160 to +160 mV). (D) Bar graph showing differences in the mean current amplitude obtained from the voltage step protocol (at −140 mV) in control and lesioned astrocytes. (E) Bar graph showing the input resistance in astrocytes in lesioned animals was significantly higher (90.9 ± 13 MΩ) than that of control animals (19 ± 5 MΩ). (F) The resting membrane potential was significantly depolarized in astrocytes from lesioned animals (−71 ± 1.4 mV) relative to control astrocytes (−77 ± 0.77 mV).