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Effect of excipients on fluorescent properties and antigenicity after exposure to heat (45 °C and 22 days)
| Excipients | Fluorescent properties | Antigenicity (%) | |
|---|---|---|---|
| λmax | I350/I329 | ||
| TT standard | 329 | 0.75 | 100 |
| None | 339 | 0.99 | 28 ± 1 |
| Histidine | 329 | 0.76 | 96 ± 22 |
| Lysine | 329 | 0.78 | 82 ± 12 |
| Trehalose | 331 | 0.82 | 44 ± 10 |
| Sorbitol | 330 | 0.78 | 83 ± 6 |
| Monomers (pH 2.9) | 335 | 0.88 | 23 ± 1 |
| MgCO3/monomers pH 5.7 | 329 | 0.78 | 88 ± 5 |
| MgCO3/monomers pH 8 | 331 | 0.82 | 56 ± 6 |
