NCT01524250.

Trial name or title	Optic Neuritis Recovery After Oral or IV Corticosteroids
Methods	Patients will be randomized to receive equivalent doses of either intravenous (IV) or oral corticosteroid treatment. Optic nerve function assessments will be compared at baseline, prior to treatment, one and six months post corticosteroid treatment. This will allow for a comparison on whether the route of medication plays a role in the effectiveness of treatment with high dose corticosteroids
Participants	Patients aged 18-65 with acute demyelinating optic neuritis already receiving high dose corticosteroids
Interventions	Intervention: 1250mg oral prednisone daily for 3 days Active comparator: 1000mg IV methylprednisolone daily for 3 days
Outcomes	Primary Outcome: P100 latency of the Visual Evoked Potential in the affected eye at 6 months Secondary Outcome: High contrast visual acuity; contrast sensitivity at one and six months, and P100 latency of the Visual Evoked Potential in the affected eye at one month
Starting date	March 2012 (estimated completion September 2014)
Contact information	Sarah A Morrow, MD, FRCPC, MSc; 519-663-2993; smorrow@uwo.ca
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