Table 3.
| a. Reclassification of Cardiovascular Disease by the Addition of each Criterion for Left Ventricular Hypertrophy, Based on a 10-year Pooled Cohort Risk Model, ARIC 1987–1989 | |||
|---|---|---|---|
| C-statistic (95% CI) | NRI, categorical (95% CI) |
IDI (p-value) | |
| Base model 1a* | 0.770 (0.755–0.785) | ||
| Sokolow-Lyon voltage | 0.770 (0.755–0.785) | 0.001 (−0.013 to 0.014) | 0.001 (p=0.03) |
| Gender-specific Cornell voltage | 0.770 (0.755–0.786) | −0.006 (−0.015 to 0.003) | 0.001 (p=0.09) |
| Romhilt-Estes point score | 0.769 (0.753–0.784) | −0.007 (−0.016 to 0.001) | 0.001 (p=0.09) |
| Framingham ECG score | 0.772 (0.757–0.787) | 0.004 (−0.008 to 0.016) | 0.002 (p=0.02) |
| Perugia score | 0.770 (0.755–0.785) | −0.008 (−0.023 to 0.007) | 0.001 (p=0.10) |
| Lewis index | 0.769 (0.754–0.785) | −0.002 (−0.008 to 0.005) | 0.0003 (p=0.14) |
| Framingham-adjusted Cornell voltage | 0.770 (0.755–0.785) | −0.002 (−0.012 to 0.009) | 0.0009 (p=0.08) |
| Cornell voltage product | 0.770 (0.755–0.786) | −0.007 (−0.018 to 0.002) | 0.0009 (p=0.13) |
| Sokolow-Lyon voltage product | 0.769 (0.754–0.784) | −0.004 (−0.014 to 0.006) | 0.0006 (p=0.23) |
| Gubner and Ungerleider voltage | 0.769 (0.754–0.785) | −0.0006 (−0.008 to 0.006 | 0.0002 (p=0.34) |
| Presence of any LVH criteria | 0.767 (0.751–0.782) | −0.006 (−0.021 to 0.007) | 0.002 (p=0.004) |
| b. Reclassification of Cardiovascular Disease by the Addition of each Left Ventricular Hypertrophy Criteria by Race, Based on a 10-year Pooled Cohort Risk Model, ARIC 1987–1989 | |||
|---|---|---|---|
| C-statistic (95% CI) | NRI | IDI | |
| Whites (n=10,727): | |||
| Base model 1a* | 0.773 (0.755–0.791) | ||
| Sokolow-Lyon voltage | 0.771 (0.753–0.789) | 0.004 (p=0.46) | 0.001 (p=0.03) |
| Gender-specific Cornell voltage | 0.773 (0.755–0.791) | −0.002 (p=0.35) | 0.0001 (p=0.45) |
| Romhilt-Estes point score | 0.772 (0.754–0.790) | −0.0004 (p=0.88) | 0.00009 (p=0.56) |
| Framingham ECG score | 0.774 (0.756–0.792) | −0.0004 (p=0.95) | 0.0005 (p=0.28) |
| Perguia score | 0.772 (0.754–0.790) | −0.005 (p=0.49) | 0.001 (p=0.06) |
| Lewis index | 0.771 (0.753–0.789) | 0.001 (p=0.75) | 0.0007 (p=0.05) |
| Framingham-adjusted Cornell voltage | 0.773 (0.755–0.791) | −0.002 (p=0.59) | 0.0004 (p=0.28) |
| Cornell voltage product | 0.773 (0.755–0.791) | −0.002 (p=0.45) | 0.0001 (p=0.59) |
| Sokolow-Lyon voltage product | 0.771 (0.753–0.789) | 0.002 (p=0.52) | 0.0004 (p=0.12) |
| Gubner and Ungerleider voltage | 0.772 (0.754–0.790) | 0.001 (p=0.44) | 0.0001 (p=0.22) |
| Any LVH criteria | 0.768 (0.750–0.786) | −0.002 (p=0.76) | 0.002 (p=0.008) |
| Blacks (n=3762): | |||
| Base model 1a* | 0.774 (0.747–0.800) | ||
| Sokolow-Lyon voltage | 0.772 (0.744–0.799) | −0.025 (p=0.15) | 0.002 (p=0.27) |
| Gender-specific Cornell voltage | 0.774 (0.748–0.800) | −0.020 (p=0.15) | 0.004 (p=0.12) |
| Romhilt-Estes point score | 0.773 (0.746–0.800) | −0.018 (p=0.17) | 0.004 (p=0.12) |
| Framingham ECG score | 0.777 (0.751–0.804) | 0.0006 (p=0.97) | 0.007 (p=0.03) |
| Perguia score | 0.769 (0.742–0.796) | −0.026 (p=0.13) | 0.010 (p=0.55) |
| Lewis index | 0.774 (0.747–0.800) | −0.005 (p=0.26) | 0.0001 (p=0.71) |
| Framingham-adjusted Cornell voltage | 0.777 (0.748–0.806) | −0.012 (p=0.43) | 0.003 (p=0.18) |
| Cornell voltage product | 0.773 (0.747–0.800) | −0.025 (p=0.07) | 0.003 (p=0.15) |
| Sokolow-Lyon voltage product | 0.772 (0.745–0.799) | −0.017 (p=0.20) | 0.0009 (p=0.55) |
| Gubner and Ungerleider voltage | 0.773 (0.747–0.799) | −0.009 (p=0.26) | 0.0001 (p=0.79) |
| Any LVH criteria | 0.765 (0.736–0.793) | −0.023 (p=0.10) | 0.002 (p=0.18) |
*
Covariates in the base model 1a are the Pooled Cohort risk equations (age, gender, race, smoking (yes/no), diabetes (yes/no), systolic blood pressure, hypertension treatment, HDL cholesterol, and total cholesterol), race, and a race*score interaction term.
†
NRI categorized as <10%, 10–20% and >20%
‡
Abbreviations: NRI = Net Reclassification Index, IDI = Integrated Discrimination Index, HR = Hazard Ratio, CI = Confidence Interval, LVH = left ventricular hypertrophy