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Cap‐dependent translation initiation and classes of IRES‐mediated initiation. (A) Schematic of canonical cap‐dependent initiation [102] and viral IRES classes. (B) Model of HCV IRES initiation. The pseudoknot at the base of domain III mimics a tRNA [51] and may position the AUG in the ribosome active site. (C) Simplified model of the c‐myc IRES element. The ribosome entry site is adjacent to an RNA pseudoknot [102].
