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. Author manuscript; available in PMC: 2015 Jun 4.
Published in final edited form as: Nature. 2014 Nov 24;516(7529):116–120. doi: 10.1038/nature13955

Extended Data Fig. 8. Schematic model of TRIM37-directed transcriptional repression and Kaplan-Meier analysis comparing survival of breast cancer patients expressing high or low TRIM37 expression.

Extended Data Fig. 8

a, Schematic models for canonical (left) and TRIM37 (right) pathways for target gene silencing. b, Kaplan-Meier analysis of survival of patients with low (black) or high (red) TRIM37 expression. The number of surviving patients at 0, 5, 10 and 15 year time-points is indicated below the graph. High expression of TRIM37 was significantly correlated with lower survival rate (p value = 0.00046, hazard ratio (HR) = 1.46 with 95% confidence interval 1.18–1.81). The analysis was performed using an online survival analysis tool to analyze the effect of gene expression on breast cancer prognosis using microarray data of 1809 patients41.