Table 1.

Baseline, 6-month and 1-year cardiac MRI Results from TIME

	BMC					Placebo
				CI					CI
	N	mean	SD	LB	UB	N	mean	SD	LB	UB	P-value*	P-value†	P-value‡
LVEF
3 day	65	46.2	9.6	43.9	48.5	30	46.3	8.5	43.3	49.3
6 month	65	50.1	11.8	47.2	53.0	30	51.5	11.2	47.5	55.5	≤0.001	0.20
1 year	65	49.5	12.3	46.5	52.5	30	49.6	10.7	45.8	53.4	≤0.001		0.30
Regional Infarct Zone (mm)
3 day	65	3.8	4.9	2.6	5.0	30	4.6	4.6	3.0	6.2
6 month	65	5.8	6.6	4.2	7.4	30	8.1	6.4	5.8	10.4	≤0.001	0.58
1 year	65	6.2	5.9	4.8	7.6	30	6.4	5.8	4.3	8.5	≤0.001		0.67
Regional Border Zone (mm)
3 day	65	16.4	10.2	13.9	18.9	30	14.4	9.8	10.9	17.9
6 month	65	20.6	11.6	17.8	23.4	30	21.1	13.4	16.3	25.9	≤0.001	0.49
1 year	65	21.2	12.0	18.3	24.1	30	21.2	13.2	16.5	25.9	≤0.001		0.00
Infarct Size (g)
3 day	63	44.7	23.1	39.0	50.4	30	46.3	27.4	36.5	56.1
6 month	63	30.7	15.4	26.9	34.5	30	31.7	20.2	24.5	38.9	≤0.001	0.04
1 year	63	28.8	15.4	25.0	32.6	30	27.7	17.2	21.5	33.9	≤0.001		≤0.001
LV Mass (g)
3 day	63	180.4	47.6	168.6	192.2	30	177.3	46.1	160.8	193.8
6 month	63	156.8	41.0	146.7	166.9	30	161.3	42.6	146.1	176.5	≤0.001	0.00
1 year	63	148.9	41.8	138.6	159.2	30	151	44	135.3	166.7	≤0.001		0.00
LVEDVI (ml/m2)
3 day	65	77.1	18.0	72.7	81.5	30	70.5	17.1	64.4	76.6
6 month	65	86.7	25.0	80.6	92.8	30	80.3	22.8	72.1	88.5	≤0.001		0.14
1 year	65	88.7	25.0	82.6	94.8	30	82.6	22.4	74.6	90.6	≤0.001		≤0.001
LVESVI (ml/m2)
3 day	65	41.9	13.5	38.6	45.2	30	38	11.7	33.8	42.2
6 month	65	44.7	20.3	39.8	49.6	30	40	17.6	33.7	46.3	0.08	0.02
1 year	65	46.3	21.3	41.1	51.5	30	42.9	18.4	36.3	49.5	0.00		0.02

BMC=bone marrow cells; CI=confidence interval; LB=lower bound; UB=upper bound; LVEF=Left Ventricular Ejection Fraction; LVEDVI=left ventricular end-diastolic volume index; LVESI=left ventricular end-systolic volume index

^*vs. Day 3

^†1 year vs. 6 month

^‡change in the mean value from baseline through six months to one year using a repeated measures mixed model