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. 2014 Dec 17;9(12):e115106. doi: 10.1371/journal.pone.0115106

Figure 5. Proximity of lens marker and Pax6-GFP or Six3-GFP expressing mES cells.

Figure 5

(A–F) mES cell cultures transduced with Pax6-GFP under the constitutive E1a promoter show close proximity but generally non-overlapping expression of GFP with γA-crystallin (A–C) or Tdrd7 (D–F) at 21 days. (G–I) Similar results were obtained for E1a driven Six3-GFP transduction and γA-crystallin expression. These results suggest recruitment of undifferentiated mES cells to a lens fate by Pax6- or Six3-expressing cells. Scale bar: A–I 30 µm.