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. 2014 Dec 17;9(12):e115184. doi: 10.1371/journal.pone.0115184

Table 2. Correlation coefficients (Pearson–correlation moment products) and significance levels (p–values) of total of area under the curve (AUC) of growth hormone (GH) and basal growth hormone concentrations with anthropometric measures, parameters of the baseline clinical lab, OGTT outcomes, as fasting endogenous glucose production, hepatic insulin extraction, values of insulin sensitivity and indexes of insulin secretion in non- acromegalic (NonACRO) and acromegalic (ACRO) subjects separated.

Total AUC of GH (ng/mL x min) GH 0 min (ng/mL)
NonACRO ACRO NonACRO ACRO
Sex (% females) r = −0.042, p = 0.596 r = −0.191, p = 0.272 r = −0.156, p = 0.049 r = −0.206, p = 0.236
Age (years) r = −0.169, p = 0.032 r = −0.189, p = 0.276 r = −0.157, p = 0.047 r = −0.214, p = 0.217
Weight (kg) r = −0.250, p = 0.001 r = 0.174, p = 0.316 r = −0.155, p = 0.05 r = 0.167, p = 0.337
Height (cm) r = 0.07, p = 0.375 r = 0.206, p = 0.235 r = 0.168, p = 0.034 r = 0.216, p = 0.214
BMI (kg/m2) r = −0.306, p<0.001 r = 0.094, p = 0.589 r = −0.247, p = 0.002 r = 0.07, p = 0.688
Systolic blood pressure (mmHg) r = −0.034, p = 0.676 r = 0.044, p = 0.812 r = 0.034, p = 0.678 r = 0.011, p = 0.952
Diastolic blood pressure (mmHg) r = −0.129, p = 0.113 r = −0.102, p = 0.578 r = 0.032, p = 0.693 r = −0.178, p = 0.331
Creatinine (mg/dL) r = 0.009, p = 0.911 r = 0.05, p = 0.775 r = 0.112, p = 0.155 r = 0.055, p = 0.752
Total cholesterol (mg/dL) r = −0.097, p = 0.226 r = −0.421, p = 0.016 r = −0.124, p = 0.121 r = −0.384, p = 0.03
HDL cholesterol (mg/dL) r = −0.013, p = 0.869 r = −0.293, p = 0.104 r = −0.002, p = 0.983 r = −0.311, p = 0.084
LDL cholesterol (mg/dL) r = −0.048, p = 0.554 r = −0.423, p = 0.016 r = −0.083, p = 0.302 r = −0.373, p = 0.035
Triglycerides (mg/dL) r = −0.199, p = 0.013 r = 0.152, p = 0.406 r = −0.208, p = 0.009 r = 0.156, p = 0.395
TSH (µU/mL) r = 0.244, p = 0.002 r = 0.024, p = 0.893 r = 0.011, p = 0.891 r = 0.033, p = 0.85
Glucose 0 min (mg/dL) r = −0.233, p = 0.003 r = 0.1, p = 0.566 r = −0.178, p = 0.024 r = 0.111, p = 0.526
Glucose 120 min (mg/dL) r = −0.077, p = 0.331 r = −0.063, p = 0.72 r = −0.045, p = 0.573 r = −0.072, p = 0.679
Insulin 0 min (µU/mL) r = −0.244, p = 0.002 r = 0.586, p<0.001 r = −0.201, p = 0.011 r = 0.544, p = 0.001
Growth hormone 0 min (ng/mL) r = 0.755, p<0.001 r = 0.972, p<0.001 - -
Total AUC of OGTT glucose (mg/dL x min) r = −0.161, p = 0.042 r = 0.046, p = 0.794 r = −0.135, p = 0.088 r = 0.051, p = 0.77
Total AUC of OGTT insulin (µU/mL x min) r = −0.213, p = 0.007 r = 0.453, p = 0.006 r = −0.122, p = 0.122 r = 0.362, p = 0.033
Total AUC of OGTT C-peptide (ng/ml x min) r = −0.243, p = 0.002 r = 0.415, p = 0.013 r = −0.148, p = 0.061 r = 0.3, p = 0.08
Dynamic AUC of OGTT glucose (mg/dL x min) r = −0.104, p = 0.189 r = 0.012, p = 0.945 r = −0.093, p = 0.241 r = 0.014, p = 0.935
Dynamic AUC of OGTT insulin (µU/mL x min) r = −0.195, p = 0.013 r = 0.334, p = 0.05 r = −0.101, p = 0.202 r = 0.243, p = 0.16
Dynamic AUC of OGTT C-peptide (ng/ml x min) r = −0.196, p = 0.013 r = 0.196, p = 0.258 r = −0.096, p = 0.227 r = 0.083, p = 0.634
Total AUC of OGTT growth hormone (ng/mL x min) - - r = 0.755, p<0.001 r = 0.972, p<0.001
Dynamic AUC of OGTT growth hormone (ng/mL x min) r = −0.454, p<0.001 r = −0.372, p = 0.028 r = −0.927, p<0.001 r = −0.58, p<0.001
Total AUC of growth hormone per total AUC of glucose (ng/mL x min per g/dL x min) r = 0.95, p<0.001 r = 0.984, p<0.001 r = 0.696, p<0.001 r = 0.948, p<0.001
Dynamic AUC of growth hormone per total AUC of glucose (ng/mL x min per g/dL x min) r = −0.448, p<0.001 r = −0.299, p = 0.081 r = −0.903, p<0.001 r = −0.513, p = 0.002
Fasting endogenous glucose production (mg/kg/min) r = −0.168, p = 0.033 r = 0.141, p = 0.42 r = −0.211, p = 0.007 r = 0.138, p = 0.429
Hepatic insulin extraction (0–120 min OGTT) (%) r = 0.136, p = 0.093 r = −0.352, p = 0.038 r = 0.087, p = 0.286 r = −0.336, p = 0.048
CLIX (mg/kg/min) r = 0.286, p<0.001 r = −0.192, p = 0.269 r = 0.156, p = 0.048 r = −0.156, p = 0.371
OGIS 120 min (ml/min/m2) r = 0.278, p<0.001 r = −0.152, p = 0.384 r = 0.112, p = 0.158 r = −0.072, p = 0.682
HOMA-IR r = −0.255, p = 0.001 r = 0.535, p = 0.001 r = −0.210, p = 0.008 r = 0.502, p = 0.002
QUICKI r = 0.358, p<0.001 r = −0.446, p = 0.007 r = 0.329, p<0.001 r = −0.413, p = 0.014
Basal insulin secretion rate (pmol/min) r = −0.246, p = 0.002 r = 0.613, p<0.001 r = −0.183, p = 0.02 r = 0.569, p<0.001
Fasting beta-cell function (nmol/mmol), prehepatic r = −0.229, p = 0.003 r = 0.641, p<0.001 r = −0.179, p = 0.023 r = 0.573, p<0.001
Fasting beta-cell function (pmol/mmol), posthepatic r = −0.224, p = 0.004 r = 0.617, p<0.001 r = −0.185, p = 0.019 r = 0.567, p<0.001
Insulinogenic Index (total insulin AUC, 0–120 min) (pmol/mmol) r = −0.178, p = 0.024 r = 0.446, p = 0.007 r = −0.092, p = 0.248 r = 0.347, p = 0.041
Adaptation Index (ml min−1m−2) x (nmol/mmol) r = −0.045, p = 0.572 r = 0.299, p = 0.081 r = −0.042, p = 0.597 r = 0.238, p = 0.168
Disposition Index (ml min−1m−2) x (nmol/mmol) r = −0.147, p = 0.063 r = 0.401, p = 0.017 r = −0.085, p = 0.285 r = 0.354, p = 0.037
WHOSH_CP r = −0.153, p = 0.053 r = 0.245, p = 0.156 r = −0.169, p = 0.032 r = 0.227, p = 0.191