Table 3. Multiple linear regression analyses with total area under the curve (AUC) of oral glucose tolerance test (OGTT) growth hormone and baseline ( = 0 min) growth hormone as dependent variables, and systolic blood pressure, sex, age, body mass index (BMI) and insulin sensitivity, determined by the Clamp–like Index (CLIX) as predictors, in all participants, all insulin resistant (IR) combined, all insulin sensitive (IS) combined, and non- acromegalic (NonACRO) subjects combined, with IR and IS subgroups, and all acromegalic (ACRO) combined, again with subgroups.

	Total AUC of OGTT growth hormone						Growth hormone 0 min
		Systolic blood pressure	Sex (f = 1, m = 0)	Age	BMI	Insulin sensitivity (CLIX)		Systolic blood pressure	Sex (f = 1, m = 0)	Age	BMI	Insulin sensitivity (CLIX)
All participants
r	0.334						0.363
B±SE				−26.3±6.1	−25.2±15.1	−62±21.9			−2.9±1.4	−0.2±0.1	−0.2±0.1	−0.4±0.2
p-value				<0.001	0.097	0.005			0.04	<0.001	0.057	0.02
All IR combined
r	0.456						0.533
B±SE				−35.1±8.8	−57.8±21	−431.7±132.7			−4.3±1.6	−0.2±0.1	−0.4±0.1	−3.2±0.9
p-value				<0.001	0.007	0.002			0.008	<0.001	0.004	<0.001
All IS combined
r	0.208						0.265
B±SE				−13.5±7.2						−0.2±0.1		−0.4±0.3
p-value				0.063						0.024		0.159
All NonACRO
r	0.363						0.298
B±SE					−4.0±1.9	9.0±2.9			−1.1±0.4		−0.07±0.04	0.10±0.06
p-value					0.031	0.002			0.019		0.064	0.068
IR-NonACRO
r	0.394						0
B±SE		0.8±0.4		−1.5±0.9	−5.2±1.8	−19.7±11.9
p-value		0.053		0.098	0.005	0.102
IS-NonACRO
r	0.288						0.318
B±SE						12.7±5.1			−2.2±0.9		−0.2±0.1
p-value						0.016			0.025		0.08
All ACRO
r	0.381						0
B±SE				−37.9±22.9		−153.6±87.3
p-value				0.108		0.089
IR-ACRO
r	0.514						0.755
B±SE						−1061.9±406.1			−9.7±4.5	−0.3±0.1		−7.3±2.3
p-value						0.017			0.045	0.067		0.006
IS-ACRO
r	0						0
B±SE
p-value

The regression coefficient (r) with B± standard error of the mean (SE) and p-value is given for each outcome; in case the model did not yield satisfactory results, an r–value of 0 is listed.