Skip to main content
. 2014 Dec 17;9(12):e115283. doi: 10.1371/journal.pone.0115283

Figure 6. Exposure to 3 hr acute maternal separation (AMS) in 14-day old pups reduces rRNA levels and increases DNA methylation at CG_6.

Figure 6

Three hours of maternal separation in 14-day old pups increased plasma levels of corticosterone (A), reduced rRNA levels in the hippocampus (B), and increased DNA methylation at the rDNA promoter (C), most notably CG_6 site (D). Unpaired Student t tests (A, B, D), Repeated measures ANOVA followed by simple-effect analysis (C). Error bars represent mean ± SEM, *p<0.05, **p<0.01.