Figure 3. Macroscopic wound healing and histological wound width and wound area.

(A) Four-mm-diameter wounds were inflicted and healing was recorded by photography. Bar, 5 mm. (B) Ratios of wound areas to initial area on day 0 are shown on line graphs for each day. (C) Histological wound width (µm) and (D) histological wound area (µm²) are shown on box graphs. Values are expressed as mean ±SD, n = 4–6 for each group, ANOVA, Tukey-Kramer ^†p<0.1, ^*p<0.05, ^**p<0.01 (in black): Control SHAM versus PM SHAM, ^†p<0.1, ^*p<0.05, ^**p<0.01 (in red): Control SHAM versus PM OVX, ^†p<0.1,^*p<0.05 (in green): Control SHAM versus PM OVX+17β-estradiol and ^¶p<0.05 (in green): PM OVX+17β-estradiol versus PM SHAM, and t-test ^ap<0.05, ^aap<0.01: day 3 versus day 7.