. Author manuscript; available in PMC: 2015 Aug 1.

Published in final edited form as: Obstet Gynecol. 2014 Aug;124(2 0 1):307–315. doi: 10.1097/AOG.0000000000000372

Table 5.

Multivariable Analysis of Predictors of the Quality of Life in Cancer Questionnaire (QLQ-C30) Functional Scales and Symptom Scales

Variables Includes in Each Multivariable Model	Functioning Scales						Symptom Scales/Items
Variables Includes in Each Multivariable Model	Global QOL	Physical Function	Role Function	Emotional Function	Cognitive Function	Social Function	Fatigue	Pain	Dyspnea
Intercept	91.2	129.1	124.1	73.6	83.0	105.5	−1.2	−5.7	−10.4
LEL/BMI classification at the time of the survey
No LEL, BMI <30 kg/m²	Reference	Reference	Reference	Reference	Reference	Reference	Reference	Reference	Reference
LEL, BMI <30 kg/m²	−11.8^*	−9.0	−8.4	−12.0^*	−10.1^*	−13.1^*	18.2^*	15.1^*	9.5
No LEL, BMI 30–39 kg/m²	−3.5	−5.1	−1.5	−0.18	−1.5	−1.9	4.1	5.1	6.6
LEL, BMI 30–39 kg/m²	−13.1^*	−16.2^*	−11.5^*	−8.4	−8.7	−8.2	16.3^*	16.5^*	15.4^*
No LEL, BMI ≥40 kg/m²	−4.0	−9.2	−2.7	−3.1	6.0	−6.2	2.6	9.7	1.9
LEL, BMI ≥40 kg/m²	−22.1^*	−31.6^*	−25.9^*	−15.1^*	−9.0	−21.5^*	26.7^*	29.4^*	27.1^*
Age at survey (per 5 years)	−0.50	−2.5	−2.0	1.4	0.56	−0.62	1.1	0.79	0.82
FIGO stage III/IV (vs. I/II)	−2.5	0.04	−2.9	−2.8	−7.0	1.1	1.6	−7.1	−4.0
Time from surgery to survey (per 5 years)	−0.01	−1.1	−1.1	−1.7	−1.2	0.04	−1.2	2.3	1.9
External beam irradiation therapy (vs. no)	2.0	−1.6	−1.3	3.3	5.3	−5.8	−0.28	0.65	4.9
Heart failure or CHF (vs. no)	−8.5	−10.8^*	−11.2^*	−3.1	−2.1	−8.9	6.4	0.02	16.1^*
Kidney disease or failure (vs. no)	−5.0	−6.9	−15.0^*	−6.7	−7.4	−8.9	7.9	3.5	0.46
Diabetes or high blood sugar (vs no)	−3.1	−1.2	0.93	−1.0	2.1	−3.1	−0.01	0.65	0.27

BMI, body mass index; CHF, congestive heart failure; FIGO, International Federation of Gynecology and Obstetrics; LEL, lower-extremity lymphedema.

P<0.05 for values in boldface type.

Meets or exceeds the minimally important difference of 10 points and denotes clinically significant differences.

^†

Higher functional scores indicate better functional well-being.

^‡

Higher symptom scores indicate worse symptom

The regression coefficients for the variables included in the nine multivariable models are summarized in the table. All functional^† and symptom^‡ scales were significantly worse in women with lower-extremity lymphedema.