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. Author manuscript; available in PMC: 2014 Dec 17.
Published in final edited form as: Gastroenterology. 2009 Nov 10;138(2):550–561.e8. doi: 10.1053/j.gastro.2009.11.002

Figure 6.

Figure 6

Changes in gastric acidity and gastrin and somatostatin cell number in control and HKCre/ShhKO mice. Gastric acid measurements (microequivalents H+/Kg) in PBS- or histamine (HIST)-treated (A) control and (B) HKCre/ShhKO mice at 1–8 months of age. Morphometric analysis of (C) gastrin (G)- and (D) somatostatin (SOM)-expressing cells in antrums of control and HKCre/ShhKO mice is shown. Electron micrographs of 4-month-old (E) control and (F) HKCre/ShhKO mouse glandular stomach. cn, canalicular membrane; n, nucleus; m, mitochondria. Scale bar = 2 µm. Representative micrograph of 6 individual animals. Data are expressed as the mean ± SEM where *P < .05 compared with control or PBS-treated group, n = 6–8 animals per group.