Figure 6.

Illustration of local shape differences (P values) between the APOE e4 noncarriers (e3/e3, N =322) and heterozygous carriers (e3/e4, N = 262; a), between the APOE e4 noncarriers (e3/e3, N = 322) and homozygous carriers (e4/e4, N = 81; b), in the full ADNI cohort. Nonblue colors show vertices with statistical differences, at the nomial 0.05 level, uncorrected. The overall significances after multiple comparisons with permutation test are P < 0.0031 for (a) and P < 0.0001 for (b). [Color figure can be viewed in the online issue, which is available at http://wileyonlinelibrary.com.]