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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Shock. 2015 Jan;43(1):92–98. doi: 10.1097/SHK.0000000000000263

Figure 3. Effect of multi-dose cyclophosphamide on survival and neutrophil counts after CLP.

Figure 3

Survival and neutrophil counts were observed in male ICR mice after CLP-induced sepsis for 28 days after treatment with imipenem and either saline vehicle (white circles) or Cyclophosphamide (non-circle, colored points). The cyclophosphamide-treated animals received 4–8 daily intraperitoneal injections of cyclophosphamide (10–20 mg/kg) after CLP via an 18g needle and 1 perforation. Low dose cyclophosphamide is associated with a survival advantage but no change in circulating neutrophils in mice that underwent CLP. There was a trend toward decreased survival in higher CyP dosing regiments (A and C), but there was significant increased survival with lower dose CyP (Part E, *p=0.05). Serial measurements of peripheral neutrophil counts were obtained. The data are cumulative of separate experiments (n=8–24 per group).