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| Dose Level | Oxaliplatin mg/m2(day 1) | Ifosfamide mg/m2/day (days 1,2,3) | Etoposide mg/m2/day (days 1,2,3) | No. of patients (No. evaluable) | DLT (No. of patients) |
|---|---|---|---|---|---|
| 1 | 130 | 1,500 | 75 | 4 (3) | Neutropenia (2) |
| 0 | 130 | 1,200 | 75 | 6 (6) | Neutropenia (1) |
| 0+filgrastim | 130 | 1,200 | 75 | 4 (3) | None |
| 1+filgrastim | 130 | 1,500 | 75 | 3 (3) | None |
| 2+filgrastim | 130 | 1,500 | 100 | 2 (2) | None |
Abbreviation: DLT, dose-limiting toxicity
