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| Course 1 (N = 17) | Course 2-7 (N= 42) | |||
|---|---|---|---|---|
| Toxicity | Grade 3 | Grade 4 | Grade 3 | Grade 4 |
| Hematologic | ||||
| Thrombocytopenia | 4 | 3 | 8 | 25 |
| Neutropenia | 2 | 9 | 6 | 18 |
| Leukopenia | 5 | 5 | 7 | 11 |
| Anemia | 1 | 2 | 20 | 2 |
| Non-hematologic | ||||
| Hypokalemia | 1 | 6 | ||
| Febrile neutropenia | 2 | 3 | 1 | |
| Hypophosphatemia | 2 | 2 | ||
| Vomiting | 1 | 3 | ||
| Infection | 3 | |||
| Diarrhea | 2 | 1 | ||
| Hemorrhage | 2 | |||
| Allergic reaction/hypersensitivity | 1 | |||
| Anorexia | 1 | |||
| AST elevation | 1 | |||
| Hyponatremia | 1 | |||
| PTT Elevation | 1 | |||
Abbreviation: N, total number of courses
