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. Author manuscript; available in PMC: 2016 May 1.
Published in final edited form as: J Magn Reson Imaging. 2014 Jun 17;41(5):1332–1341. doi: 10.1002/jmri.24672

Table 2.

Metabolite ratios quantified using LCModel (mean ± standard deviation) and significance (p-value) was tested on metabolite ratios between the T2L or GM and the NAWM.

G2 T2L (N=12) G3 T2L (N=10) G4 T2L (N=7) NAWM (N=29) GM (N=29)
tCho/tCr 0.31±0.08 0.26±0.07 0.29±0.04 0.24±0.03 0.18±0.04
P=0.0137 P=0.0051 P < 0.0001
NAA/tCr 1.15±0.29 1.33±0.31 1.07±0.20 1.51±0.16 1.37±0.19
P=0.0001 P=0.0479 P=0.0002 P=0.0027
tCho/NAA 0.30±0.17 0.20±0.08 0.28±0.07 0.16±0.03 0.13±0.03
P<0.0001 P<0.0001 P=0.0002
Glu/tCr 0.99±0.17 1.07±0.34 1.00±0.26 1.19±0.16 1.53±0.25
P=0.0012 P<0.0001
Gln/tCr 0.74±0.36 (N=10) 0.91±0.34 (N=6) 0.80±0.21 0.50±0.21 (N=19) 0.61±0.40 (N=17)
P=0.0352 P=0.0090 P=0.0028
Glx/tCr 1.27±0.24 1.49±0.55 (N=9) 1.37±0.34 1.24±0.15 1.61±0.27
P<0.0001
GSH/tCr 0.33±0.05 0.32±0.12 0.30±0.06 0.23±0.05 0.21±0.05
P<0.0001 P=0.0224 P=0.0062
mI/tCr 1.07±0.36 1.00±0.26 0.86±0.24 0.66±0.14 0.61±0.10
P=0.0001 P=0.0004 P=0.0108
Gly/tCr 0.31±0.10 0.36±0.19 (N=9) 0.33±0.08 0.20±0.05 0.17±0.03
P=0.0001 P=0.0060 P=0.0003 P=0.0344
mIG/tCr 1.16±0.29 1.13±0.31 1.02±0.22 0.81±0.14 0.75±0.09
P=0.0006 P=0.0010 P=0.0319
mI/tCho 3.61±1.62 4.30±1.62 3.09±0.95 2.85±0.49 3.67±0.81
P=0.0046 P<0.0001
GABA/tCr 0.48±0.08 (N=8) 0.54±0.07 (N=6) 0.50±0.10 (N=6) 0.52±0.06 0.54±0.11

N = number of patients; G2 = grade II; G3 = grade III; G4 = grade IV.