Table 2.

Metabolite ratios quantified using LCModel (mean ± standard deviation) and significance (p-value) was tested on metabolite ratios between the T2L or GM and the NAWM.

	G2 T2L (N=12)	G3 T2L (N=10)	G4 T2L (N=7)	NAWM (N=29)	GM (N=29)
tCho/tCr	0.31±0.08	0.26±0.07	0.29±0.04	0.24±0.03	0.18±0.04
	P=0.0137		P=0.0051		P < 0.0001
NAA/tCr	1.15±0.29	1.33±0.31	1.07±0.20	1.51±0.16	1.37±0.19
	P=0.0001	P=0.0479	P=0.0002		P=0.0027
tCho/NAA	0.30±0.17	0.20±0.08	0.28±0.07	0.16±0.03	0.13±0.03
	P<0.0001		P<0.0001		P=0.0002
Glu/tCr	0.99±0.17	1.07±0.34	1.00±0.26	1.19±0.16	1.53±0.25
	P=0.0012				P<0.0001
Gln/tCr	0.74±0.36 (N=10)	0.91±0.34 (N=6)	0.80±0.21	0.50±0.21 (N=19)	0.61±0.40 (N=17)
	P=0.0352	P=0.0090	P=0.0028
Glx/tCr	1.27±0.24	1.49±0.55 (N=9)	1.37±0.34	1.24±0.15	1.61±0.27
					P<0.0001
GSH/tCr	0.33±0.05	0.32±0.12	0.30±0.06	0.23±0.05	0.21±0.05
	P<0.0001	P=0.0224	P=0.0062
mI/tCr	1.07±0.36	1.00±0.26	0.86±0.24	0.66±0.14	0.61±0.10
	P=0.0001	P=0.0004	P=0.0108
Gly/tCr	0.31±0.10	0.36±0.19 (N=9)	0.33±0.08	0.20±0.05	0.17±0.03
	P=0.0001	P=0.0060	P=0.0003		P=0.0344
mIG/tCr	1.16±0.29	1.13±0.31	1.02±0.22	0.81±0.14	0.75±0.09
	P=0.0006	P=0.0010	P=0.0319
mI/tCho	3.61±1.62	4.30±1.62	3.09±0.95	2.85±0.49	3.67±0.81
		P=0.0046			P<0.0001
GABA/tCr	0.48±0.08 (N=8)	0.54±0.07 (N=6)	0.50±0.10 (N=6)	0.52±0.06	0.54±0.11

N = number of patients; G2 = grade II; G3 = grade III; G4 = grade IV.