. Author manuscript; available in PMC: 2015 Oct 15.

Published in final edited form as: Clin Cancer Res. 2014 Jul 21;20(20):5157–5170. doi: 10.1158/1078-0432.CCR-13-0866

Table 1.

Immunosuppressive myeloid progenitors in cancer

A. Mouse
Name	Ontogeny	Phenotype	Other Markers	Progeny
Gr-MDSC	Granulocytic	CD45⁺ CD11b⁺ Gr1^high Ly6C^int	Ly6G⁺ CXCR1⁺ CXCR2⁺	Potentially Neutrophils
Mo-MDSC	Monocytic	CD45⁺ CD11b⁺ Gr1^int Ly6C^high	CCR2⁺ CD115⁺ CD62L⁺ CX₃CR1^−/low	High plasticity: Macrophages, Dendritic cells, resident monocytes, fibrocytes
Inflammatory monocytes	Monocytic	CD45⁺ CD11b⁺ Gr1^int Ly6C^high	CCR2⁺ CD115⁺ CD62L⁺ CX₃CR1^−/low	High plasticity: Macrophages, Dendritic cells, Resident monocytes, Fibrocytes, Mo-MDSC
Resident monocytes¹	Monocytic	CD45⁺ CD11b⁺ Ly6C⁻ CX₃CR1^high	CCR2⁻ CD62L⁻	M2 Macrophages
Fibrocytes	Monocytic	CD45⁺ CD34⁺ Collagen⁺	CXCR1⁺ CXCR4⁺	Fibroblasts

B. Human
Name	Ontogeny	Phenotype	Other Markers	Progeny
Gr-MDSC	Granulocytic	CD45⁺ Lin⁻ CD11b⁺ CD14⁻ HLA- DR^lowCD33⁺	CD15⁺ CD66b⁺	Potentially Neutrophils
Mo-MDSC	Monocytic	CD45⁺ Lin⁻ CD11b⁺CD14⁺ HLA-DR^low CD33⁺	CD66b⁺	High plasticity: Macrophages, Dendritic cells, resident monocytes, fibrocytes
Inflammatory monocytes	Monocytic	CD45⁺ Lin⁻ CD14⁺ HLA-DR⁺ CD33⁺	CCR2⁺ CD115⁺ CD62L⁺ CD15^−/low CXCR4⁺	High plasticity: Macrophages, Dendritic cells, Resident monocytes, Fibrocytes, Mo-MDSC
Resident monocytes¹	Monocytic	CD45⁺ CD14⁺ CD16⁺ CX₃CR1^high CD33^dim	CD115⁺ CD62L⁻ CXCR4⁺	M2 Macrophage
Fibrocytes	Monocytic	CD45⁺ CD34⁺ Collagen⁺	α-SMA⁺ HLA-DR⁺ CXCR1⁺ CXCR4⁺	Fibroblasts

Although resident monocytes (RM) have not been well studied during cancer, during other inflammatory contexts, RM have a propensity to differentiate into wound-healing (M2) macrophages after extravasation and thus may contribute to macrophage heterogeneity in solid tumors.