. Author manuscript; available in PMC: 2015 Oct 15.

Published in final edited form as: Clin Cancer Res. 2014 Jul 21;20(20):5157–5170. doi: 10.1158/1078-0432.CCR-13-0866

Table 2.

Immature myeloid progenitors in representative human cancers

Cancer	Subset	Putative suppressive mechanism	Phenotype	Other Markers	Ref
Metastatic melanoma	Mo-MDSC	--	CD45⁺ Lin⁻ CD14⁺ HLA-DR^−/low	CD15^dimCD66b⁻ CD33⁺ Arg⁻ CD16^−/low	(17)
Metastatic melanoma	Gr-MDSC	--	CD45⁺ Lin⁻ CD14⁻ CD15⁺ CD33⁺ HLA-DR^−/low	Arg⁺ CD16^−/low	(17)
Metastatic Melanoma	Mo-MDSC	TGFβ	CD45⁺ CD14⁻ HLA-DR^−/low	--	(19)
Metastatic Melanoma	Mo-MDSC	PGE₂ STAT3 COX2 Superoxide	CD14⁺ HLA-DR^−/low	--	(22)
Metastatic Melanoma	Mo-MDSC	STAT3 Arg	CD45⁺ HLA-DR^−/low CD14⁻	CD80⁺CD83⁺ CD209⁺	(95)
Metastatic Melanoma	Mo-MDSC	--	HLA-DR^−/low CD86^low	--	(96)
Pediatric sarcomas	Fibrocytes	IDO	CD14⁻ CD66b⁺ CD33^int/low CD15⁺ CD123⁻ CD11c⁺	α-SMA⁺ Collagen⁺ CXCR1⁺ MMP9⁺ TSLPR⁺ CD127⁺	(20)
Non-small-cell lung cancer	Mo-MDSC	ROS	CD11b⁺ CD14⁺ HLA-DR^−/low	CD86^low CD16^low	(21)
Non-small-cell lung cancer	Gr-MDSC	Arg1 iNOS suppression of CD3ζ	CD11b⁺ CD14⁻ CD15⁺ CD33⁺	SSC^high IL-4R⁺ IFNγR⁺	(97)
Glioblastoma	Mo-MDSC	TGFβ IL-10 B7H1	Lin⁻ HLA-DR^−/low CD33⁺	B7H1⁺	(29)
Renal cell carcinoma	Gr-MDSC	Low arginine: ornithine ratio in plasma correlated with decreased CD3ζ	CD11b⁺ CD15⁺ CD14⁻ CD33⁺	--	(98)
Colorectal cancer	Gr-MDSC	--	Lin^−/low HLA-DR⁻ CD11b⁺ CD33⁺	CD14⁻ CD13⁺ CD117⁺ CD39⁺ SSC^high	(99)
GI malignancies¹	Mo-MDSC	--	CD14⁺ HLA-DR^−/low	--	(26)
GI malignancies¹	Gr-MDSC	--	CD15⁺ CD14⁻ CD11b⁺ CD33⁺	--	(26)
Metastatic pancreas, colon, & breast adenocarcinomas	Gr-MDSC	H₂0₂-mediated suppression of CD3ζ	CD15⁺ CD11b⁺ Low density	--	(36)
Ovarian cancer	Mo-MDSC	--	CD11b⁺ CD14⁺ CD33⁺ CXCR4⁺	MDSC correlated w/PGE₂ and CXCL12 in ascites	(54)
Numerous solid tumors	--	--	CD11b⁺ Lin^−/Lo HLA-DR⁻ CD33⁺	--	(100)
Multiple myeloma	Mo-MDSC	PDE5 NOS2 Arg	CD14⁺ cells	--	(101)
Hepatocellular carcinoma	--	--	Lin^−/low CD33⁺ HLA-DR⁻	COX-2, MMP-13, and VEGF correlated with MDSC	(102)
Hepatocellular carcinoma	Gr-MDSC	--	CD11b⁺CD14 ⁻ HLA-DR⁻CD33⁺	--	(103)
GM-CSF induced MDSC from normal blood	Gr-MDSC	NOS TGFβ, NADPH oxidase Arg	CD11b⁺ HLA-DR^−/low CD33⁺	CD66b⁺	(38)

Colorectal, pancreatic, hepatocellular, and gastric cancer.