Skip to main content
. 2014 Jun 24;3(2):83–102. doi: 10.1007/s40121-014-0029-7

Fig. 1.

Fig. 1

INSTI pathways of HIV-1 resistance with associated dissociative t 1/2 and fold change in EC50 [19] compared to wild-type virus. Diss t 1/2 dissociative values previously reported [20, 21]. Major integrase mutations are denoted in black bold: E92Q/V; Y143C/H/R; Q148H/K/R; N155H. Accessory mutations are denoted in gray: E138A/K; G140A/C/S [25]. DTG dolutegravir, EC 50 half-maximal effective concentration, EVG elvitegravir, FC fold change, INSTI integrase strand transfer inhibitor, ND not determined, RAL raltegravir, t 1/2 half-life