Table 3.

Probability of achieving pharmacodynamic exposure thresholds in serum (a) and interstitial fluid of tissue (b) for cefazolin 1 g and 2 g q8h dosing regimens from 5,000 patient Monte Carlo simulation

MIC (mg/L)	1 g q8h			2 g q8h
	30% fT > MIC	50% fT > MIC	100% fT > MIC	30% fT > MIC	50% fT > MIC	100% fT > MIC
(a) Serum
0.125	1.00	0.99	0.96	1.00	0.99	0.96
0.25	0.99	0.99	0.93	1.00	0.99	0.96
0.5	0.99	0.98	0.84	0.99	0.99	0.93
1	0.99	0.97	0.66	0.99	0.98	0.84
2	0.98	0.79	0.41	0.99	0.97	0.66
4	0.77	0.61	0.08	0.98	0.79	0.41
8	0.33	0.09	0.01	0.77	0.61	0.08
16	0.03	0.01	0.00	0.34	0.09	0.01
(b) Interstitial fluid of tissue
0.125	0.99	0.98	0.93	0.99	0.99	0.95
0.25	0.99	0.97	0.89	0.99	0.98	0.93
0.5	0.98	0.96	0.77	0.99	0.97	0.89
1	0.96	0.91	0.58	0.98	0.96	0.77
2	0.87	0.71	0.39	0.96	0.91	0.58
4	0.58	0.45	0.20	0.87	0.71	0.39
8	0.29	0.18	0.08	0.58	0.45	0.20
16	0.10	0.07	0.03	0.29	0.18	0.08

fT > MIC Free time above MIC, q8h every 8 h