Table 1.
Comparison of SGLT1 and SGLT2
| Characteristic | SGLT1 | SGLT2 |
|---|---|---|
| Location | Small intestine; later part of PCT (segment 3) | Early PCT (segment 1, 2) |
| Capacity | Low | High |
| Affinity | High | Low |
| Contribution to glucose reabsorption | 10% | 90% |
| Disease state if mutation/deficiency occurs | Glucose-galactose malabsorption | Familial renal glucosuria |
| Physical manifestations of disease state | Diarrhea at few days age | None |
| Course | Fatal without glucose free/galactose free diet | Benign |
| Inhibitors | Phlorizin | Currently available SGLT2i |
PCT proximal convoluted tubule, SGLT sodium-glucose co-transporter, SGLT2i sodium-glucose co-transporter-2 inhibitors