Fig. 4.

Central delivery of G-CSF increases whole body metabolism and physical activity levels. Central administration of G-CSF had an acute and transient effect on whole body metabolism and physical activity. V̇o₂ (A), energy expenditure (B), and physical activity levels (C) were increased at 1 h following intracerebroventricular delivery of G-CSF. V̇o₂ (D), energy expenditure (E), and physical activity (F) levels were not different between the groups at 4 h. Data shown are means ± SE (n = 10 for saline control; n = 10 for G-CSF). *P < 0.05.