Table 3.

Summary of serum cytokine levels in mice fed a low-fat diet or a high-fat diet

	LFD	HFD	P Value	Cytokine	LFD	HFD	P Value
Cytokines
sCD30**	106 ± 17	30 ± 6	0.0001	IL-17	10 ± 5	2.3 ± 0.4	0.17
sgp130	549 ± 96	461 ± 77	0.48	IL-20	16 ± 0.2	23 ± 5	0.21
IFN-γ	7.4 ± 2	4.2 ± 1	0.17	IL-22**	20 ± 3	4 ± 0.4	0.0001
IL-1α	812 ± 173	903 ± 134	0.68	IL-25	983 ± 141	644 ± 116	0.08
IL-1β	30 ± 17	10 ± 1	0.27	IL-27	16 ± 4	20 ± 5	0.55
IL-2	2.8 ± 0.5	2.3 ± 0.4	0.44	IL-28B	273 ± 31	295 ± 31	0.61
IL-4	6.4 ± 4.4	2 ± 0.4	0.33	IL-33	7 ± 2.4	2 ± 1	0.20
IL-5	18 ± 5	13 ± 2	0.47	sIL-1RI	814 ± 173	596 ± 59	0.25
IL-6	13 ± 5	9 ± 1	0.39	sIL-1RII	11153 ± 280	10328 ± 633	0.25
IL-7	8 ± 3	3 ± 0.3	0.15	sIL-2Rα	348 ± 27	470 ± 141	0.41
IL-9	68 ± 16	88 ± 20	0.44	sIL-4R	3043 ± 418	2083 ± 226	0.06
IL-10	18 ± 10	8 ± 2	0.33	sIL-6R	8641 ± 383	8179 ± 864	0.63
IL-12p40*	13 ± 3	5 ± 1.4	0.01	PTX-3	11 ± 1.3	15 ± 2.5	0.15
IL-12p70	16 ± 5	13 ± 3	0.66	TNF-α	8 ± 3.2	4 ± 0.5	0.19
IL-13	114 ± 10	175 ± 63	0.35	sTNFRI	6596 ± 639	6260 ± 412	0.66
IL-15	17 ± 8	6 ± 2	0.22	sTNFRII	3836 ± 261	4727 ± 450	0.10
IL-16**	29785 ± 4681	14150 ± 2183	0.006
Chemokines
CCL11	623 ± 34	657 ± 17	0.39	CXCL2	85 ± 13	82 ± 25	0.90
CCL12**	77 ± 8	44 ± 4	0.001	CCL19	121 ± 14	84 ± 17	0.11
CCL21	2888 ± 479	2533 ± 181	0.50	CCL22	19 ± 3	15 ± 1.4	0.31
CX3CL1**	2090 ± 125	1518 ± 48	0.005	CXCL9	129 ± 23	150 ± 25	0.54
CXCL1**	74 ± 8	123 ± 10	0.001	CCL2	54 ± 19	49 ± 6	0.81
CXCL10	152 ± 18	181 ± 19	0.27	CCL20*	32 ± 5	18 ± 3	0.01
CXCL5	8481 ± 1007	10268 ± 1083	0.24	CCL5	22 ± 3	20 ± 3	0.67
CCL3	43 ± 8	52 ± 7	0.38	CCL17	56 ± 7	44 ± 5	0.15
CCL4*	62 ± 10	36 ± 7	0.03
Growth and Differentiation Factors
G-CSF	396 ± 71	292 ± 54	0.25	VEGF	12 ± 3	17 ± 9	0.62
GM-CSF	20 ± 7	16 ± 4	0.56	sVEGFR1	2003 ± 330	1656 ± 123	0.35
M-CSF	689 ± 372	190 ± 119	0.22	sVEGFR2	28350 ± 1991	28960 ± 1776	0.82
TIMP-1**	289 ± 45	535 ± 59	0.004	sVEGFR3	30035 ± 1081	30228 ± 1417	0.92
Other Cytokines
sRAGE*	178 ± 46	51 ± 7	0.03	A2M*	412 ± 19	492 ± 24	0.02
Lipocalin-2	24 ± 3	28 ± 4	0.39	Haptoglobin**	29 ± 3	15 ± 2	0.002
SAA-3**	94 ± 26	173 ± 23	0.003	SAP	1126 ± 386	770 ± 152	0.40
Adipsin	20 ± 0.6	20 ± 0.8	0.96	CRP	11 ± 1	10 ± 0.2	0.33
AGP	0.06 ± 0.01	0.1 ± 0.01	0.03

Except for A2M, adipsin, AGP, haptoglobin, SAP, PTX3, and SAA-3 (ng/ml), all other values are pg/ml.

LFD, low-fat diet; HFD, high-fat diet.

^*P < 0.05;

^**P < 0.005.