Fig. 2.

Kinetics of the increase in fluorescence measured in the cytosol (A) and canaliculi (B), measured in images collected from the livers of living rats 42 days following either 5/6N (red symbols) or sham surgery (blue symbols). Each point represents the mean ± SE of the measurements collected from five rats, each representing the mean of measurements of 22–32 hepatocytes. Overall transport kinetics are very similar for the two conditions. C: mean initial rates of uptake (measured during the first 30 s following perfusion). D: mean rates of secretion (measured during the subsequent 90-s interval). The mean rate of uptake was reduced by 20.7% in the 5/6th nephrectomy group (P = 0.024, one tailed Student's t-test). The mean rate of secretion did not differ between the two groups (P = 0.470, one-tailed Student's t-test).