Fig. 1.

A–C: mean (± SE) skeletal muscle capillary blood volume (CBV) in wild-type mice (A), microvascular blood flow (MBF) in wild-type mice (B), and both CBV and MBF in db/db mice (C) at baseline and after administration of trans-4-[4-(3-adamantan-1-ylureido)cyclohexyloxy]benzoic acid (t-AUCB; 1 mg/kg iv) or vehicle (wild-type mice only). *P < 0.05 vs vehicle; †P < 0.05 vs. baseline. D: relation between db/db mouse age and MBF either at baseline or for peak value after administration of t-AUCB. Baseline: y = −9.5X + 126, r² = 0.71, P = 0.009. t-AUCB: y = −0.2X + 82, r² < 0.01, P = 0.95.