Fig. 5.

Cardiac expression of metabolic (Sirtuin 3, Sirtuin 6, and PGC1a) and senescence (short:long endoglin) markers measured by quantitative PCR in the LV of control and Sirt1^endo−/− animals at different ages. mRNA expression of Sirtuin 6 (A) and Sirtuin 3 (B) decreased with age in the myocardium of Sirt1^endo−/− animals. PGC1a mRNA abundance (C) was not different from control animals. Compared with control mice, the mRNA expression of short:long endoglin (D) increased in the Sirt1^endo−/− mice with aging.