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Cardiac expression of metabolic (Sirtuin 3, Sirtuin 6, and PGC1a) markers measured by quantitative PCR in the LV of control animals without surgery, control animals with TAC, and Sirt1endo−/− TAC animals 7 wk after surgery. A: mRNA expression of Sirtuin 3 in the LV decreased in both TAC groups. B: Sirtuin 6 mRNA expression levels in the LV remained similar between the different groups. C: mRNA expression of PGC1a in the LV decreased in both constricted groups.
