Fig. 1.

Light-phase, time-restricted feeding (tRF) shifts the peak of the core body temperature (Temp) to the light phase. A: depiction showing how light phase-restricted feeding selectively influences the timing of peripheral organ metabolism (clocks) relative to the light-dark cycle and the timing of circadian oscillations in the suprachiasmatic nucleus. B: core body temperature data plotted as the half-hour mean for ad libitum (Ad Lib)-fed (■) and tRF conditions (○) for wild-type (WT; left) and Scn5a^+/ΔKPQ (right) mice (n = 6 animals each). Zeitgeber time (ZT) = 0 is the onset of the light phase and the shaded region signifies the dark phase.