Table 1.

Scn5a^+/ΔKPQ mice show a time-of-day prolongation in their QTc interval that is flipped after light phase-restricted feeding

Genotype	Ad Libitum QTc Light	Ad Libitum QTc Dark	tRF QTc Light	tRF QT Dark	n
WT	41.3 ± 1.4	42.0 ± 0.4	44.7 ± 0.8	45.5 ± 0.9	6
Scn5a+/ΔKPQ	48.3 ± 1.1*	43.1 ± 1.2†	50.0 ± 1.3*	55.9 ± 1.0*†	7

Values are means ± SE; n, number of mice. Shown are the average heart rate-corrected QT (QTc) intervals calculated using the correction formula: QTc = QT/(RR₁₀₀)^0.5 [see Mitchell et al. (17)]. The QTc intervals were calculated from ECG traces recorded during the hours that corresponded to Zeitgeber time (ZT) =5 (light) and ZT =17 (dark) in ad libitum-fed or tRF conditions.

^*P < 0.05, wild-type (WT) vs. Scn5a^+/ΔKPQ;

^†P < 0.05, light vs. dark.