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. 2014 Oct 17;307(12):H1754–H1763. doi: 10.1152/ajpheart.00377.2014

Fig. 1.

Fig. 1.

Endothelium-dependent and endothelium-independent dilation. Dose responses to the endothelium-dependent dilator acetylcholine (ACh; A) and endothelium-independent dilator sodium nitroprusside (SNP; B) in young control (YC), young SRT1720-treated (YS), old vehicle-control (OV), and old SRT1720-treated (OS) mice. Dose responses to ACh (C) and SNP (D) in YC and young vehicle-treated (YV) mice. Values are means ± SE. ACh: YC, n = 38; OV, n = 17; YS, n = 24; OS, n = 28; YV, n = 11. SNP: YC, n = 23; OV, n = 11; YS, n = 13; OS, n = 17; YV, n = 6. Differences in dose-response curves were assessed with repeated-measures ANOVA. Least squares differences post hoc test was used to determine individual group differences to ACh. *P < 0.01 vs. YC; †P < 0.01 vs. OV.